1309 Elevated 17-Hydroxyprogesterone [17-Ohp] Levels: A Fetoplacental Mechanism to Prevent Preterm Birth?
نویسندگان
چکیده
منابع مشابه
Pharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth: a case-control study.
OBJECTIVE To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17-alpha hydroxyprogesterone caproate (17-P) administration for the prevention of recurrent preterm birth (PTB). DESIGN Case-control. SETTING Three tertiary-care centres across the USA. POPULATION Women (n = 99) with ≥ 1 prior singleton spontaneous PTB, receiving ...
متن کاملPrevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate
From Wake Forest University, WinstonSalem, N.C. (P.J.M.); the National Institute of Child Health and Human Development, Bethesda, Md. (M.K., C.Y.S.); the Biostatistics Center, George Washington University, Rockville, Md. (E.T.); Wayne State University, Detroit (M.P.D.); the University of Tennessee, Memphis (B.S.); the University of Chicago, Chicago (A.H.M.); the University of Alabama, Birmingha...
متن کاملOBSTETRICS : Pharmacogenomics of 17 - alpha hydroxyprogesterone caproate for recurrent preterm birth prevention
OBJECTIVE—We hypothesized that genetic variation affects responsiveness to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth prevention. STUDY DESIGN—Women of European ancestry with ≥1 spontaneous singleton preterm birth at <34 weeks’ gestation who received 17P were recruited prospectively and classified as a 17P responder or nonresponder by the difference in delivery gest...
متن کاملPossible andrologic markers in elevated neonatal 17-hydroxyprogesterone.
In this prospective study, we analyzed 30 male infants with increased neonatal 17-hydroxyprogesterone (17OH-P) (patients) and for comparison 52 age-matched healthy babies (control subjects) with the aim of investigating the hypothalamic-pituitary-testis axis in the first 6 months of life. Although T, FSH, and LH levels were not significantly different in patients and control subjects, inhibin B...
متن کاملPrevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2012
ISSN: 0003-9888,1468-2044
DOI: 10.1136/archdischild-2012-302724.1309